ACIDOS MICOLICOS PDF

Publicada em 2 de nov de Enviar pesquisa. O slideshow foi denunciado. Mycobacterium Tuberculosis.

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Rational approach in the new antituberculosis agent design: inhibitors of InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis. Unitermos: Tuberculose. In conjunction with the spread of HIV infection, tuberculosis TB has been among the worldwide health threats. Mycobacteria resistance to the drugs currently used in the therapeutics is the main cause of TB resurgence. In view of this severe situation, the new and selective anti-TB design is of utmost importance.

Fatty acid biosynthesis is a prokariontes and eucariontes biochemical process that supplies essential precursors for the assembly of important cellular components, such as phospholipids, lipoproteins, lipopolysaccharides, mycolic acids and cellular envelope. However, the biochemical and functional differences between the bacterial and mammals' fatty acid synthetic pathway have endowed the mycobacterial enzymes with distinct properties. These provide valuable opportunities for structure- or catalytic mechanism-based design of selective inhibitors as novel anti-TB drugs with improved properties.

The enoyl-reductases are essential enzymes in the fatty acids elongation pathway towards the mycolic acids, the main mycobacteria cell wall constituents, biosynthesis and so they are potential targets to the rational new antimycobacteria drug design.

This paper highlights recent approaches regarding the design of new anti-TB agents, particularly, the enoyl-ACP reductase inhibitors.

Uniterms: Tuberculosis. Mycolic acids. Mycobacteria drug resistance. Rozwaski et al. Em geral, as tiofeno-diazoborinas foram os inibidores mais potentes, seguidos pelas benzo-diazoborinas e furano-diazoborinas, enquanto que as pirrol-diazoborinas foram totalmente inativas.

Estes pesquisadores isolaram cepas de E. Foram utilizados Mechanism of action of diazaborines. A mechanism of drug action revealed by structural studies of enoyl reductase.

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Rational approach in the new antituberculosis agent design: inhibitors of InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis. Unitermos: Tuberculose. In conjunction with the spread of HIV infection, tuberculosis TB has been among the worldwide health threats. Mycobacteria resistance to the drugs currently used in the therapeutics is the main cause of TB resurgence. In view of this severe situation, the new and selective anti-TB design is of utmost importance. Fatty acid biosynthesis is a prokariontes and eucariontes biochemical process that supplies essential precursors for the assembly of important cellular components, such as phospholipids, lipoproteins, lipopolysaccharides, mycolic acids and cellular envelope. However, the biochemical and functional differences between the bacterial and mammals' fatty acid synthetic pathway have endowed the mycobacterial enzymes with distinct properties.

EXOTIQUE BALLISTIC PDF

Identificación de especies micobacterianas en Cuba

Estudiante de doctorado en Medicina Tropical. Universidad de Cartagena. Docente Investigadora Universidad de Cartagena. Directora regional Doctorado Medicina Tropical.

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