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Ethnopharmacologic relevance: Artemisia herba-alba Asso "desert wormwood" in English; "armoise blanche" in French; "shaih" in Arabic , is a medicinal and strongly aromatic plant widely used in traditional medicine by many cultures since ancient times.
It is used to treat inflammatory disorders colds, coughing, bronchitis, diarrhea , infectious diseases skin diseases, scabies, syphilis and others diabetes, neuralgias. In Jordanian traditional medicine, this plant is used as antiseptic and against skin diseases, scabies, syphilis, fever as well as menstrual and nervous disorders.
Aim of the study: Considering the traditional medicinal uses and the lack of scientific studies addressing the cellular and molecular players involved in these biological activities, the present study was designed to unveil the antifungal and anti-inflammatory activities of A.
Materials and methods: Chemical analysis of A. The antifungal activity minimal inhibitory concentrations and minimal lethal concentrations was evaluated against yeasts, dermatophyte and Aspergillus strains. In order to explore the mechanisms behind the anti-fungal effect of the essential oil, the germ tube inhibition assay was evaluated using Candida albicans. The assessment of cell viability was accomplished using the 3- 4,5-dimethylthiazolyl -2,5-diphenyltetrazolium bromide MTT assay and the in vitro anti-inflammatory potential of A.
Results: Oxygen-containing monoterpenes are the main compounds of the oil, namely 1,8-cineole Among the fungal strains tested, the oil demonstrated potential against Trichophyton rubrum and Epidermophyton floccosum, with minimal inhibitory concentration MIC and minimal lethal concentration MCL values of 0. The oil revealed a strong inhibitory effect on germ tube formation in C. Importantly, the essential oil significantly inhibited NO production evoked by LPS without cytotoxicity at concentrations up to 1.
Furthermore, evaluation of cell viability in RAW Conclusions: It was possible to find appropriate doses of A.
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Publication types Research Support, Non-U. Gov't Actions. MeSH terms Animals Actions. Dose-Response Relationship, Drug Actions.
Jordan Actions. Mice Actions. Substances Anti-Inflammatory Agents Actions. Antifungal Agents Actions. Oils, Volatile Actions. Plant Oils Actions. Full-text links [x] Elsevier Science. Copy Download.
Fungicidal Activity of Artemisia Herba Alba Asso (Asteraceae)
Artemisia herba-alba , the white wormwood , is a perennial shrub in the genus Artemisia that grows commonly on the dry steppes of the Mediterranean regions in Northern Africa Saharan Maghreb , Western Asia Arabian Peninsula and Southwestern Europe. Its specific epithet herba-alba means "white herb" in Latin , as its stems and leaves are white and woolly. Leaves are strongly aromatic and covered with fine glandular hairs that reflect sunlight giving a grayish aspect to the shrub. The leaves of sterile shoots are grey, petiolate , ovate to orbicular in outline; whereas, the leaves of flowering stems, more abundant in winter, are much smaller. The flowering heads are sessile , oblong and tapering at base.