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Objective: To validate the Hartford nomogram for once-daily aminoglycoside dosing in trauma surgery patients. Methods: A chart review was performed in trauma surgery patients who were started on once-daily aminoglycoside therapy. A peak aminoglycoside concentration was drawn 30 minutes after the end of the first or second infusion, and a random concentration was drawn approximately 10 hours after the dose. The percentage of intervals accurately predicted by the nomogram was determined.
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Send even when there aren't any new results. Optional text in email:. Save Cancel. Create a file for external citation management software Create file Cancel. Full-text links Cite Favorites. Abstract Objective: To validate the Hartford nomogram for once-daily aminoglycoside dosing in trauma surgery patients. Similar articles Evaluation of four once-daily aminoglycoside dosing nomograms. Wallace AW, et al. Asempa TE, et al. Clin Ther. Epub Jun Comment: validation of the Hartford nomogram in trauma surgery patients.
Groves S. Ann Pharmacother. PMID: No abstract available. Clinical pharmacokinetics and pharmacodynamics of isepamicin. Tod M, et al. Clin Pharmacokinet. PMID: Review. Aminoglycoside dosing considerations in intensive care unit patients.
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Roberts JA, et al. Lancet Infect Dis. Epub Apr Therapeutic drug monitoring of antimicrobials. Br J Clin Pharmacol. Aminoglycoside dosage regimens after therapeutic drug monitoring. Kirkpatrick CM, et al. Pharmacokinetics and therapeutic drug monitoring of gentamicin in the elderly. Triggs E, Charles B. Triggs E, et al.
Publication types Clinical Trial Actions. MeSH terms Adult Actions. Aged Actions. Aminoglycosides Actions. Area Under Curve Actions. Body Weight Actions. Female Actions. Humans Actions.
Intensive Care Units Actions. Male Actions. Middle Aged Actions. Retrospective Studies Actions. Substances Aminoglycosides Actions. Anti-Bacterial Agents Actions. Full-text links [x] Atypon. Copy Download.
This dose is used to determine the patient's true corrected peak value. Click this icon button to either include or ignore the patient's dose for the calculation. This aminoglycoside calculator uses a variety of published pharmacokinetic equations and principles to estimate an appropriate aminoglycoside regimen. This regimen can be completely empiric, where the dose is based on body weight, height, and creatinine clearance, or a regimen may be calculated based on one or more drug levels.
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Validation of the Hartford Nomogram in Trauma Surgery Patients