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Need more advice on solubility, usage and handling? Please email to: service chemfaces. ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use 1. Reference standards 2. Pharmacological research 3. Arjunolic acid. CAS No. Citing Use of our Products. More Impact Factor than five Cite Orders via your E-mail: 1.
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Description: Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic AChE and BuChE activities, it may as promising targets for the development of innovative multi-functional medicines for Alzheimer desease treatment.
Arjunolic acid protects cardiac tissues from both extrinsic and intrinsic cell death pathways. Arjunolic acid exhibits better protection against histamine release than against acetylcholine release, anti-asthmatic and anaphylactic activity of it may be possibly due to membrane stabilizing potential and inhibition of antigen induced histamine and acetylcholine release. Arjunolic acid protects cardiac tissues from both extrinsic and intrinsic cell death pathways, it also has antitumor activity.
Arjunolic acid: a new multifunctional therapeutic promise of alternative medicine. Indeed, tremendous demand for the development and implementation of these plant derived biomolecules in complementary and alternative medicine is increasing and appear to be promising candidates for pharmaceutical industrial research. These new molecules, especially those from natural resources, are considered as potential therapeutic targets, because they are derived from commonly consumed foodstuff and are considered to be safe for humans.
Studies on the biochemistry and pharmacology suggest the potential use of Arjunolic acid as a novel promising therapeutic strategy.
The scientific basis behind its therapeutic application as a cardioprotective agent in traditional medicine is justified by its ability to prevent myocardial necrosis and apoptosis, platelet aggregation, coagulation and lowering of blood pressure, heart rate, as well as cholesterol levels.
Its antioxidant property coupled with metal chelating property by its two hydroxyl groups protects different organs from metal and drug-induced organ pathophysiology. Arjunolic acid also plays a beneficial role in the pathogenesis of diabetes and its associated complications. The mechanism of cytoprotection of Arjunolic acid , at least in part, results from the detoxification of reactive oxygen species ROS produced in the respective pathophysiology.
In addition to its other biological functions, it also possesses vibrant insecticidal properties and it has the potential to be used as a structural molecular framework for the design of molecular receptors in the general area of supramolecular chemistry and nanochemistry.
Esters of Arjunolic acid function as organogelators which has wide application in designing thermochromic switches and sensor devices. Arjunolic acid derived crown ether is an attractive candidate for the design of molecular receptors, biomimetics and supramolecular systems capable of performing some biological functions. This review also aims to untie the multifunctional therapeutic application of Arjunolic acid , a nanometer-long naturally occurring chiral triterpenoid biomolecule.
Biomed Pharmacother. EAC was induced in fifty female Swiss albino mice. Arjunulic acid reduced tumor volume and cells count. AA decreased EAC cells viability and increased cell toxicity. Antiallergic and anti-asthmatic activities of the alcoholic extract of Terminalia arjuna and arjunolic acid. TA and AA also protected the guinea pig against histamine as well as acetylcholine induced bronchospasm.
In vivo: Life Sci. Protective effects of arjunolic acid against cardiac toxicity induced by oral sodium nitrite: effects on cytokine balance and apoptosis. On the other hand, Arjunolic acid possesses antioxidant properties and plays protective roles against chemically induced organ pathophysiology.
We investigated the effect of sodium nitrite on cardiac tissue in rats on the inflammatory cytokine balance and the type of induced apoptosis, and we analyzed the protective role of Arjunolic acid. Cardiac mitochondrial activity cytochrome-C-oxidase , JNK activation and apoptosis caspase-3, caspase-8 and caspase-9 were assessed.
Arjunolic acid markedly ameliorated these effects. Moreover, Arjunolic acid protected cardiac tissues from both extrinsic and intrinsic cell death pathways. J Biochem Mol Toxicol. Cisplatin-induced testicular toxicity in rats: the protective effect of arjunolic acid. Source: The fruits of Terminalia chebula Retz.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months C. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at C.
Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals.
Cell Metab. Mol Cell. ACS Nano. Nature Plants. Sci Adv. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Kinase Assay: Biochimie. Protective effect of arjunolic acid against atorvastatin induced hepatic and renal pathophysiology via MAPK, mitochondria and ER dependent pathways. Its application is restricted now-a-days due to several acute and chronic side effects. ATO induced anti hypercholesterolemia and hepatic tissue toxicity has been reported to follow different mechanisms. Histological studies and DNA fragmentation analysis also support the toxic effect of ATO in these organs pathophysiology.
Arjunolic acid in the ethanolic extract of Combretum leprosum root and its use as a potential multi-functional phytomedicine and drug for neurodegenerative disorders: Anti-inflammatory and anticholinesterasic activities. Modes of action of arjunolic acid and derivatives on Trypanosoma cruzi cells. Its chemotherapy is poorly selective and effective, associated to severe side effects and unresponsive cases.
Electron microscopy analysis revealed remarkable effects on the parasite surface and architecture. AA-treated parasites displayed minutely corrugated plasma membranes devoid of subpellicular microtubules as well as biogenesis of multiple basal bodies. As the AA effects appeared mainly restricted or originated at the parasite peripheral cytoplasm, including the cytoskeleton membrane linkage, we inferred that the compound targeted primarily the lipid bilayer; therefore, we performed synthetic modification to increase the molecule lipophilicity and thus membrane permeability.
Parasites cultured with both derivatives displayed numerous and large autophagic vacuoles, altered flagellar length and cell body connection. CFN 2,3-Dihydroxyoleanenoic acid Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic AChE and BuChE activities, it may as promising targets for the development of innovative multi-functional medicines for Alzheimer desease treatment.
In recent years, a number of studies describing the effective therapeutic strategies of medicinal plants and their active constituents in traditional medicine have been reported.
In the present study, the alcoholic extract of Terminalia arjuna TA and Arjunolic acid AA were studied for its anti-asthmatic and anaphylactic activity. Life Sci. Sodium nitrite, a preservative used in meat products, helps in the production of free radicals, leading to increased lipid peroxidation, which plays a vital role in posing toxic effects in different body organs.
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months C. The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial.
Combretum leprosum Mart. Curr Top Med Chem. Chagas disease causes considerable morbimortality in the Americas, with circa 7 to 8 million infected people, causing at least 12, annual deaths and million people at risk. Bayogenin methyl ester. Polygalacic acid. Phytolaccagenic acid.
Arjunolic Acid: A Novel Phytomedicine With Multifunctional Therapeutic Applications
Herbal plants with antioxidant activities are widely used in Ayurvedic medicine for cardiac and other problems. Arjunolic acid is one such novel phytomedicine with multifunctional therapeutic applications. It is a triterpenoid saponin, isolated earlier from Terminalia arjuna and later from Combretum nelsonii, Leandra chaeton etc. Arjunolic acid is a potent antioxidant and free radical scavenger. The scientific basis for the use of arjunolic acid as cardiotonic in Ayurvedic medicine is proven by its vibrant functions such as prevention of myocardial necrosis, platelet aggregation and coagulation and lowering of blood pressure, heart rate and cholesterol levels. Its antioxidant property combined with metal chelating property protects organs from metal and drug induced toxicity.
Showing metabocard for Arjunolic acid (HMDB0034502)
We'd like to understand how you use our websites in order to improve them. Register your interest. Arjunolic acid, the major extractable constituent of the heavy wood of Terminalia Arjuna , has the potential to be used as a rigid and functional molecular framework for the construction of nanosized supramolecular architectures and nanomaterials. The nanosized triterpenoid, arjunolic acid, showed efficient gelation of various organic solvents at low concentrations.
Arjunolic acid: A promising new building block for nanochemistry
A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. A molecular entity capable of donating a hydron to an acceptor Br o nsted base. Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.