Special emphasis is put on problems that have been encountered in the installation and operation of the different phases of the OPAL microvertex detector leading to the present Phase III detector and their cures. A short description of the new OPAL radiation monitoring and beam dump system is also given. Most RCTs are sponsored by the pharmaceutical industry, which reflects industry's increasing responsibility in cancer drug development. Many preclinical models are unreliable for evaluation of new anticancer agents, and stronger evidence of biologic effect should be required before a new agent enters the clinical development pathway. Whenever possible, early- phase clinical trials should include pharmacodynamic studies to demonstrate that new agents inhibit their molecular targets and demonstrate substantial antitumor activity at tolerated doses in an enriched population of patients. Here, we review recent RCTs and found that these conditions were not met for most of the targeted anticancer agents, which failed in recent RCTs.
|Genre:||Health and Food|
|Published (Last):||14 July 2013|
|PDF File Size:||2.62 Mb|
|ePub File Size:||17.30 Mb|
|Price:||Free* [*Free Regsitration Required]|
Directory of Open Access Journals Sweden. In San Jorge Gulf , several important economic activities are developed, including two industrial fisheries: hake Merluccius hubbsi Marini, and Argentine red shrimp Pleoticus muelleri Bate, Both overlap spatially and temporally. The main problem of both fisheries is the bycatch of hake in one of its. Levels of essential and toxic elements in Porphyra columbina and Ulva sp.
Elements were quantified by inductively coupled plasma-optical emission spectrometry, with the exception of lead and cadmium in some samples which were determined by electrothermal atomic absorption spectrometry. Three stations with different exposure degree to human activities, Bahia Solano, the mouth of Arroyo La Mata stream and Punta Maqueda, were selected as sampling points. The results showed a wide range of metal retention capacity between the two studied species.
Regarding the levels of pollutants found in the researched sites, Punta Maqueda seemed to be less influenced by anthropogenic activities than the other two sites except for Cd. Taking into account their toxicities seasonal variations in Pb and Cd levels were studied in both algae in Punta Maqueda.
Maximum concentrations of Cd 9. Legislative and health safety aspects were evaluated for Cd and Pb. E-mail: copipat sinectis. In the future the uranium exploration activities of CNEA would tend to improve the knowledge of geology and uranium favorability; to perform prospection tasks, and research and development in exploration technologies, to contribute to be in a position to meet the requirements of the country in the long term.
On the other hand, a strong growth of nuclear capacity is expected in the first two decades of the next century. Based on its promising grade, the Cerro Solo uranium ore deposit was selected in by the CNEA to carry out an assessment project. The intensive exploration level was accomplished, as follows: definition of general characteristics of the main orebodies; detailed geologic studies; estimation of resources with adequate data; and preliminary selection of mining-milling methods to estimate the potential profitability of the project.
The deposit belongs to the sandstone type. The mineralized layers are distributed into the fluvial sandstones and conglomerates of the cretaceous Chubut Group, lying 50 to m deep Resources of the deposit, with an average grade of 0. Follow-up drilling programmes are being performed at present in some of the target sites defined in the paleochannel that hosts the Cerro Solo deposit, in order to establish the hypothetical resources of the area.
The sites were determined as a result of the exploration that CNEA conducted in the Pichinan uranium district. Recently a regional research project was formulated, for the detailed exploration in the San Jorge Gulf Basin, where the Chubut Group is distributed. An extensive series of high-resolution satellite images from the advanced very high-resolution radiometer AVHRR and the sea-viewing wide field-of-view sensor SeaWIFS was used in a synoptic oceanographic characterization of San Jorge Gulf SJG, Argentine Patagonia , an area of great significance for marine conservation and commercial fishing.
Remotely sensed information was combined with on-board observer's data and published information to investigate the role of distinctive oceanographic features in relation to the life cycle of the Patagonian red shrimp Pleoticus muelleri , main target of the industrial fleet in SJG.
The North and South SJG fronts are associated with shrimp reproductive aggregations during late spring and summer. The thermohaline South SJG front has its maximum expression during the winter, reflecting the influence of the low-salinity Magellanic Plume, while the thermal North SJG front develops during spring and summer as the water column becomes stratified in the central basin of the gulf.
Chlorophyll a is concentrated near the thermocline on the stratified side of the North SJG, and for that reason, it is not detected by remote sensors during the spring bloom and the summer but becomes apparent offshore from the location of the front when the thermocline deepens during the fall May. In the South SJG front, Chl-a concentration is apparent inshore from the front all year-round, related in part to upwelling-mediated resuspension.
The northern end of the outer front coincides in time and space with a recurrent non-reproductive aggregation of red shrimp between November and January and is presumably related to foraging. It is argued that keeping the North and South. Paparazzo, Flavio E. We compared biological and chemical parameters in surface waters of the Gulf of San Jorge to better understand carbon export and the factors that control phytoplankton production in an area of the Argentinian Continental Shelf, a vastly under sampled region of the SW Atlantic Ocean.
In April of , we estimated new and regenerated primary production in the Gulf by measuring nitrate and ammonium uptake, respectively. We also measured macronutrient, and in situ chlorophyll-a concentrations, which were compared to chlorophyll-a estimates from remote sensing.
Although the Gulf of San Jorge presents high levels of chlorophyll-a and primary production, the relationship between these parameters is not straightforward. Previous studies showed that surface chlorophyll-a explains only part of the variance in euphotic-zone integrated primary production, and that satellite-derived chlorophyll-a underestimates in situ primary production.
Our results showed large spatial variability in the Gulf , with transitional physico-chemical conditions, such as fronts, that could favor an increase in biological production. In situ chlorophyll-a concentrations were highest at the mid-shelf station 6. Remote sensing measurements of chlorophyll-a underestimated our in situ chlorophyll-a concentrations.
Seaweed have a great capacity to accumulate heavy metals in their tissues. The chemical characterization of seaweed is important due to their use in environmental monitoring and human or animal food. TXRF showed to be a suitable technique for simultaneous multi-element analysis in this kind of samples. The results revealed seasonal variations in the chemical content for some elements; arsenic content was maximum in summer and autumn, iron concentration increased to the winter and zinc concentration was maximum in autumn.
The total As concentration ranged between 36 and 66 mg kg- 1. Lead, nickel and copper were not detected. An area of Ka2 was explored to define surface mining possibilities within two subareas referred to as Alto San Jorge and San Pedro Ure. Rocks of Cretaceous, Tertiary and Quaternary age crop out in the zone. In the subarea Alto San Jorge the principal structure is a syncline with a south-north direction. The San Pedro Ure subarea is formed by undulations with flanks of low dip, the most important being the San Antonio Syncline because it contains the mining block.
The geological study of the surface demonstrated the existence of coal in the Oligocene Cienaga de Oro Formation and the Niocene Cerrito Formation, with potential resources of 6. The subsequent exploration of the subsoil, with In the sector selected for the mine plan, in the area of San Pedro-Puerto Libertador, 7.
The combustible type coal has 5. Complete mining schedules were developed at the prefeasibility level for two surface mines with productions of 1. Schenk, Christopher J. Using a geology-based assessment methodology, the U. Geological Survey estimated mean undiscovered, technically recoverable resources of 78 million barrels of oil and 8. Distribution and temporal variation of trace metal enrichment in surface sediments of San Jorge Bay, Chile.
Cu, Pb, and Hg concentrations were determined in surface sediment samples collected at three sites in San Jorge Bay, northern Chile. This study aims to evaluate differences in their spatial distribution and temporal variability. The highest metal concentrations were found at the site "Puerto", where minerals Cu and Pb have been loaded for more than 60 years.
On the other hand, Hg does not pose a contamination problem in this bay. Cu and Pb concentrations showed significant variations from 1 year to another. Differences in the contamination factor and geoaccumulation index suggest that pre-industrial concentrations measured in marine sediments of this geographical zone, were better than geological values average shale, continental crust average for evaluating the degree of contamination in this coastal system.
Based on these last two indexes, San Jorge Bay has a serious problem of Cu and Pb pollution at the three sampling locations. However, only Cu exceeds the national maximum values used to evaluate ecological risk and the health of marine environments.
It is suggested that Chilean environmental legislation for marine sediment quality--presently under technical discussion--is not an efficient tool for protecting the marine ecosystem. Factores predictores de mortalidad por accidente cerebrovascular en el Hospital Universitario San Jorge de Pereira Colombia.
Objetivo: Determinar los factores predictores de mortalidad por accidente cerebrovascular ACV en el Hospital Universitario San Jorge de Pereira entre enero de y diciembre de Do coastal fronts influence bioerosion patterns along Patagonia? Late Quaternary ichnological tools from Golfo San Jorge. Late Quaternary marine molluscan skeletal concentrations from Argentina constitute a remarkable record of variations in palaeoceanographical conditions during interglacial times mainly ca.
Particularly, the Golfo San Jorge coastal area represents an extraordinary geographical zone to target from different points of view, mainly due to its linkage between northern and southern Patagonia, characterized by particular and contrasting physico-chemical conditions with direct consequences for littoral marine communities, determining their composition and structure.
Among varied biological activities controlled by different environmental factors i. In addition, the application of bioerosion patterns regionally and through time is a recent valuable worthy palaeoenvironmental tool not as yet developed for Patagonia. Bustamante exhibits the highest ichnodiversity for the whole Argentinean coastal area.
Ichnodiversity is not strongly different between Late Pleistocene and mid-Holocene interglacials and compared to present; however, the relative abundance of some ichnotaxa e. Full Text Available La violencia y la accidentalidad son causas frecuentes de trauma en Colombia. Huinchulef, M. Universidad Nacional de Quilmes, Bernal, Argentina. Extensional deformation is recorded in the km-wide, fan-shaped Plato- San Jorge basin by a km thick, shallowing-upward and almost entirely fine-grained, upper Eocene and younger sedimentary sequence.
First-order subsidence analysis in the Plato- San Jorge basin is consistent with crustal stretching values between 1.
The model predicts about km of right-lateral displacement along the Oca fault and 45 km of left-lateral displacement along the Santa Marta-Bucaramanga fault. Full Text Available Objetivo. Electrokinetic remediation of mercury- contaminated soil, from the mine El Alacran- San Jorge river basin, Cordoba- Colombia.
La mortalidad fue mayor en los. Fault kinematics and depocenter evolution of oil-bearing, continental successions of the Mina del Carmen Formation Albian in the Golfo San Jorge basin, Argentina.
Thickness maps of the seismic sub-units that integrate the Mina del Carmen Formation, named MEC-A-MEC-C in ascending order, and mapping of fluvial channels performed applying geophysical tools of visualization were integrated to the kinematical analysis of 20 main normal faults of the field.
The study provides examples of changes in fault throw patterns with time, associated with faults of different orientations. Fault activity was localized during deposition of the MEC-A sub-unit, but generalized during deposition of MEC-B sub-unit, producing centripetal and partially isolated depocenters. Upward decreasing in fault activity is inferred by more gradual thickness variation of MEC-C and the overlying Lower Member of Bajo Barreal Formation, evidencing passive infilling of relief associated to fault boundaries, and conformation of wider depocenters with well integrated networks of channels of larger dimensions but random orientation.
Mammals, reptiles, and birds, especially the Psittacidae family, are the vertebrates most used by the indigenous communities. No kind of use was found for amphibians. The consumption of reptiles such as Iguana iguana, Tupinambis teguixin, Caiman crocodylus fuscus, and Crocodylus acutus show them to be an important part of their culture.
The indigenous communities associate environmental problems with habitat destruction due to the cultivation of illicit crops and forest clearing in the buffer zone around Paramillo National Park. Inherited discontinuities and fault kinematics of a multiphase, non-colinear extensional setting: Subsurface observations from the South Flank of the Golfo San Jorge basin, Patagonia.
We use three-dimensional 3D seismic reflection data to analyze the structural style, fault kinematics and growth fault mechanisms of non-colinear normal fault systems in the South Flank of the Golfo San Jorge basin, central Patagonia. They control the location and geometry of wedge-shaped half grabens from the "main synrift phase" infilled with Middle Jurassic volcanic-volcaniclastic rocks and lacustrine units of Late Jurassic to Early Cretaceous age.
The NE-striking, basement-involved normal faults resulted in the rapid establishment of fault lenght, followed by gradual increasing in displacement, and minor reactivation during subsequent extensional phases; NW-striking normal faults are characterized by fault segments that propagated laterally during the "main rifting phase", being subsequently reactivated during succesive extensional phases.
Directory of Open Access Journals Sweden. In San Jorge Gulf , several important economic activities are developed, including two industrial fisheries: hake Merluccius hubbsi Marini, and Argentine red shrimp Pleoticus muelleri Bate, Both overlap spatially and temporally. The main problem of both fisheries is the bycatch of hake in one of its.
They live in the Rhone-Alpes region in France. Their singular artworks use diverse expressions: interactive installations, visual art, digital art, sound art, collective performances etc Scenocosme mix art and digital technology to find substances of dreams, poetry, sensitivity and delicacy. These artists overturn various technologies in order to create contemporary artworks. Their works came from possible hybridizations between the technology and living world plants, stones, water, wood, humans. The most of their interactive artworks feel several various relationships between the body and the environment. They can feel energetic variations of living beings and design interactive stagings in which spectators share extraordinary sensory experiences.