COXITIS TUBERCULOSIS PDF

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Although the prevalence of tuberculosis reduces, it still belongs to the most important infectious diseases worldwide even in industrial countries. We report an unusual case of tuberculous coxitis in a year-old healthy native female with recurrent hip pain. While X-ray and microbiological examination of the aspirate showed no abnormality, only extended diagnostic measurements and detailed history led to the diagnosis of TBC.

Although the patient did not show any pulmonary symptoms open tuberculosis was confirmed. After a course of antibiotic treatment she underwent reconstructive surgery which consecutively improved range of motion. This case report emphasizes that tuberculosis should still be considered as a significant disease even in healthy patients with uncertain complaints in joints without significant initial radiographic abnormalities.

We recommend the described diagnostic procedures as well as an antibiotic and surgical treatment. Although the prevalence constantly reduces [ 1 ] tuberculosis still belongs to the most important infectious diseases worldwide.

Analysis of In case of tuberculous coxitis TBC a prior pulmonary infection causes the affection of the joint by haematogenous spread. Early diagnosis can be difficult as the primary clinical symptoms at an early stage as well as radiological findings are often non-specific [ 5 ]. We report an unusual case of TBC in a year-old otherwise healthy native female with recurrent hip pain without a history of long-termed stays in foreign countries.

A year old native female patient complained about recurrent pain in the right hip joint without previous trauma progressing by physical strain starting about 1.

A MRI of the pelvis performed 3 months before admittance showed a swelling of the capsule and reduction of the cartilage in the right hip joint which was considered as an early arthritis or coxitis. After treatment with physiotherapy and oral non-steroidal antirheumatic medication the symptoms were regressive and no further diagnostic procedures were performed.

Caused by recently aggravation of pain in the right hip joint within the days before, the patient was not able to stand and walk and the range of motion ROM was painfully reduced. Blood samples were normal except slightly increased CRP of 4. X-ray of the right pelvis showed a slight joint space narrowing with affection of the acetabulum and the femoral head Fig.

An effusion was detected by ultrasound, aspiration of the hip joint led to no further diagnosis as aerobic and anaerobic cultures were sterile. The MRI showed a joint space narrowing in the cranial part of the acetabulum with increased subchondral sclerosis as well as a synovial enhancement with bone marrow edema in the femoral head and the corresponding acetabulum. Initial X-ray of the right pelvis showing only a slight joint space narrowing with affection of the acetabulum and the femoral head.

The histological result was suspicious for tuberculosis with marked granulomatous lymphadenitis and caseous degenerated confluent necrosis, but tuberculin test and sputum sample examinations by microscopy and culture medium were negative. A CT without any proof of lymphadenopathy and pulmonary infiltration could not confirm this suspicion. In addition there were no other risk factors except her profession as a veterinarian, especially as she was neither an immigrant nor had long-termed stays in foreign countries.

So no further treatment had been started at that time. Although the initial microbiological examination of the first aspirate being inconspicuous, a current Quantiferon-Test [ 7 ] showed a positive reaction as an indication of a latent or active infection with Mycobacterium tuberculosis M.

X-ray of the chest showed an enhanced parenchymal change in both apical segments. A consequently performed CT of the chest and abdomen revealed the clinical sign of reactivated tuberculosis in the apical and posterior bronchopulmonary segments with nodular peribronchiovascular focus as a sign of open lung tuberculosis.

Furthermore a second aspiration of the right hip joint confirmed M. Gastric secretion examined by polymerase chain reaction PCR as well as bacterial culture and microscopy of the sputum showed an amount of M.

Thereafter by confirming TBC and open lung tuberculosis, the patient was treated with combination of oral Isoniazid, Rifampicin, Ethambutol and Pyrazinamid. She received physiotherapy with partial weight bearing of 10 kg. Three months later X-ray showed an increasing patchy transparency in the femoral head and neck as well as in the greater trochanter and acetabulum with clear progressive joint space narrowing in the corresponding parts of the hip joint Fig.

A complementary MRI with contrast medium five months after starting therapy showed active arthritis with progressive destruction of the right hip joint and a new appearance of liquid retention in the right acetabulum as a sign of tuberculous osteomyelitis Fig. X-ray of the right pelvis 3 months after diagnosis with increasing patchy transparence in the femoral head and neck as well as in the greater trochanter and acetabulum with clear progressive joint space narrowing.

MRI 5 months after starting the oral therapy showing an active arthritis with progressive destruction of the right hip joint and liquid retention in the right acetabulum as a sign of tuberculous osteomyelitis see black arrow.

After seven months the microbiological examination of gastric secretion and sputum analysis did not detect open lung tuberculosis, so the oral therapy was reduced to double combination with Isoniazid and Rifampicin. The patient underwent reconstructive surgery by extirpation of the granuloma from the acetabulum and augmentation with autologous spongiosaplasty from the ipsilateral iliac crest.

Microbiological and microscopic examination of intraoperative swabs and surface biopsies did not detect M. Six weeks after surgery, continuing physiotherapy and oral double combination, the patient was almost free of pain and ROM was improved. X-ray of the right pelvis revealed an unchanged result compared to the examination after operation without any progression of destruction and regular positioned autologous spongiosaplasty without dislocation. The physical load for the right leg was gradually increased and ROM was continuously improved.

Ten months after starting oral therapy, a CT of the thorax detected scars without nodular pathologic infiltrates or pleural effusion in both apical parts of the lungs. The ROM of the hip joint in spite of the radiological findings with progressive sclerosis in the acetabulum and joint space narrowing Fig.

The patient was able to walk without crutches suffering only minor pain. X-ray oft the right pelvis 1 year after diagnosis showing a progressive sclerosis of the acetabulum with decreasing joint space narrowing.

Tuberculosis belongs to the most important infectious diseases worldwide. Although its prevalence in industrial countries is decreasing, it still is not eradicated.

Thus tuberculosis is considered to be a significant disease in discovering diagnosis of uncertain complaints in joints and bones. The early diagnosis could be difficult as the primary clinical symptoms and radiological findings at an early stage are often non-specific [ 5 ].

In our case the initial radiographic findings, MRI and standard blood samples were unspecific. In case of TBC prior pulmonary infection causes the affection of the joint by haematogenous spread so a consequently performed CT of the chest revealed pulmonary infiltrates as well as microbiological examinations of the gastric secretion and sputum analysis showed open tuberculosis.

Consequently, the patient must have had an exposure to M. However, there are several recommendations for the period of treatment and combination of antituberculotic medication before an operative treatment [ 11 , 12 ] to reduce potential risk of reactivation of infection.

Furthermore different surgical techniques as arthrotomy with debridement, arthrodesis, Girdlestone resection arthroplasty or total hip arthroplasty THA [ 13 - 18 ] have been performed in cases of extensive disease [ 5 , 19 ]. Although Girdlestone resection arthroplasty is not difficult to perform and in most of the cases clinical results are satisfactory [ 20 - 22 ], the major disadvantage of this technique is loss of function due to reduced hip offset.

Arthrodesis as an alternative represents to reduce pain and in the meantime treats the infection successfully. Besides loosing ROM of the hip joint, there are often secondary degenerative changes especially of lumbar spine in the longer term.

Performing a THA should be mentioned as a demanding alternative, which is often practiced in combination with oral antituberculotic medication. Local exacerbation is observed in cases with insufficient systemic treatment, whereas in most of the cases the results referring to ROM and pain-reduction are satisfactory. In our case the patient underwent reconstructive surgery by extirpation of the granuloma in the acetabulum and augmentation with autologous spongiosaplasty after oral antituberculotic treatment.

The reason for our decision to choose a reconstructive bone-saving surgical technique was influenced by different factors. It is reported that extensive operative interventions as THA for TBC continue to be a controversial issue due to the potential risk of reactivation of infection [ 5 ]. However, the period of time after beginning oral antituberculotic treatment and performing an arthroplasty is discussed [ 23 , 24 ].

An argument against Girdlestone resection or arthrodesis was the improvement of ROM as well as the reduction of pain supported by a regular performed physiotherapy during the period before operative intervention. Furthermore the patient was young and had the compliance for a distinguished rehabilitation. Moreover she was not convinced of a more extensive surgical intervention and agreed with the operation as an attempt to improve her situation.

In conclusion this case demonstrates, that tuberculosis should still be considered as a possibility of a specific origin of joint infection in finding the diagnosis of uncertain complaints of joints without initial radiographic abnormabilities, even in otherwise healthy and young patients without obvious risk factors.

Considering the different kinds of surgical techniques and preoperative oral antituberculotic therapies, the decision for a concept of treatment is influenced by several factors as the individual situation of the patient, the compliance, ROM and the initial destruction of the joint. Furthermore the preoperative response to oral antituberculotic therapy as well as persistent histological evidence of active disease are important aspects for choosing the suitable surgical technique for operative treatment.

Finally it should be emphasized, that a decision for performing a less extensive bone-saving operative intervention for the treatment of TBC as a first step with a minimal surgical expenditure for patient and surgeon in a suitable case does not exclude further application of more extensive surgical treatment, thus the above mentioned surgical techniques could be still performed in case of failure.

HK analyzed and interpreted all patient data and was major contributor in writing the manuscript. IS was involved in revising the manuscript critically for important intellectual content. All authors read and approved the final manuscript. The authors confirm that this article content has no conflicts of interest. National Center for Biotechnology Information , U. Journal List Open Orthop J v. Open Orthop J. Published online Oct 4. Author information Article notes Copyright and License information Disclaimer.

Abstract Although the prevalence of tuberculosis reduces, it still belongs to the most important infectious diseases worldwide even in industrial countries. Keywords: Tuberculous coxitis, TBC, tuberculosis. Open in a separate window. Schweisfurth H, Link K. Clinical studies of the incidence of pulmonary and extrapulmonary tuberculosis. Tuberculosis in Germany in and Leowski J, Miller M.

Soz Praventivmed. Demographic characteristics of patients with extrapulmonary tuberculosis in Germany. Eur Respir J. Total hip arthroplasty for tuberculous coxitis. Int Orthop.

Tuberculosis of the hip: diagnostic problems. Apropos of 44 cases. J Chir Paris ; 11 —4. The evaluation of the Quantiferon-TB Gold test in pulmonary and extrapulmonary tuberculosis. J Jpn J Infect Dis. Mycobacterium bovis infection in humans exposed to elk in Alberta. Can Dis Wkly Rep.

FREDRO PAN JOWIALSKI PDF

Tuberculosis of hip: A current concept review

Metrics details. Osteoarticular tuberculosis is rare in Germany. In particular, trochanteric bursitis is an extremely rare manifestation of osteoarticular tuberculosis. We describe a case of tuberculous coxitis with trochanteric bursitis, successfully treated with a fourfold tuberculostatic therapy. We report the case of a year-old human immunodeficiency virus-negative Sudanese man with osteoarticular tuberculosis, who was originally admitted with the suspected diagnosis of ankylosing spondylitis. Low grade fever together with the positive result of an interferon-gamma release assay test as well as findings from magnetic resonance imaging provided clues to the diagnosis. A definitive diagnosis could be set after a computed tomography-guided biopsy.

A TEXTBOOK OF PHARMACEUTICAL ANALYSIS BY KENNETH A.CONNORS PDF

The Open Orthopaedics Journal

Address of Correspondence Dr. E-mail : dhandyeone gmail. Introduction: Total hip arthroplasty THA remains controversial in active tuberculosis TB infection because of the risks of septic loosening and reactivation of the infection. We present a rare case of THA in a patient positive for the human immunodeficiency virus HIV with active tuberculous coxitis. The aim of this work is to share our experience and our preliminary results. Case Report: The patient was a year-old Black African woman, positive for the HIV, who was operated for implantation of a THA via the Hardinge approach indicated for a severe painful hip with restriction of joint movement and limp.

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