Cancer of the Prostate and Kidney pp Cite as. Carcinoma of the prostate is a slowly progressive disease which may be managed in many different ways. Treatment alternatives include no treatment, surgery, irradiation, endocrine therapy and cytotoxic chemotherapy. Diagnosis is easily achieved by rectal examination and biopsy, and scanning techniques are readily available for accurate clinical staging. The common osteosclerotic metastases are not, however, easily assessed for progression or regression and other marker lesions suitable for accurate measurement do not often occur, even in advanced progressive disease. Therefore a good biological tumour marker would be invaluable to aid the clinician monitor disease progression and the response to treatment and to assess new hormonal and chemotherapeutic regimes in phase II clinical trials.
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Juan P. Brito 1,2,a , Juan P. Kargi 5,a. Rochester, EE. Miami, EE. In the regions with no iodine deficiency, it is more frequent in women and oftentimes has a familial association. The symptoms and signs of hypothyroidism are systemic and depend on the duration and intensity of the thyroid hormone deficiency. Neuromuscular manifestations are seldom the only symptoms and signs present. Antecedentes: tiroiditis de Hashimoto en la madre. En el examen de ingreso, los signos vitales eran normales.
Dentro de las principales manifestaciones musculares de la enfermedad se encuentran: las paresias de diverso grado, fatigabilidad, dolor, rigidez muscular y calambres, como los presentados por esta paciente. Cabe resaltar que elevaciones no mayores a diez veces el valor normal de CPK y no asociados a rabdomiolisis suelen ser vistos frecuentemente en hipotiroidismo. Fuentes de financiamiento: autofinanciado. Serum thyrotrophin and circulating thyroglobulin and thyroid microsomal antibodies in a Finnish population.
Acta Endocrinol Copenh. Thyroid dysfunction in adults over age 55 years. A study in an urban US community. Arch Intern Med. Autoimmune thyroid disease: further developments in our understanding. Endocr Rev. J Clin Endocrinol Metab. Neuromuscular findings in thyroid dysfunction: a prospective clinical and electrodiagnostic study.
J Neurol Neurosurg Psychiatry. Clinical and biochemical features of muscle dysfunction in subclinical hypothyroidism. Riggs JE.
Acute exertional rhabdomyolysis in hypothyroidism: the result of a reversible defect in glycogenolysis? Mil Med. The clinical presentation of hypothyroid myopathy and its relationship to abnormalities in structure and function of skeletal muscle. Clin Endocrinol Oxf.
George G. Hypothyroidism presenting as puzzling myalgias and cramps in 3 patients. J Clin Rheumatol. Myopathy associated with acute hypothyroidism following radioiodine therapy for graves disease in an adolescent.
Int J Pediatr Endocrinol. Epub Sep Doran GR. Serum enzyme disturbances in thyrotoxicosis and myxoedema. J R Soc Med. Hypothyroidism and polyneuropathy. Polyneuropathy associated with hypothyroidism. J Neuropathol Exp Neurol. Effects of thyroid hormones on skeletal muscle bioenergetics. In vivo phosphorus magnetic resonance spectroscopy study of humans and rats. J Clin Invest. Curr Opin Rheumatol. Resolution of abnormal muscle enzyme studies in hypothyroidism.
Am J Med Sci. CC Monterrico.
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