ANABOLE STEROIDE 2010 PDF

Abuse of anabolic androgenic steroids AAS has been linked to a variety of different cardiovascular side effects. In case reports, acute myocardial infarction is the most common event presented, but other adverse cardiovascular effects such as left ventricular hypertrophy, reduced left ventricular function, arterial thrombosis, pulmonary embolism and several cases of sudden cardiac death have also been reported. However, to date there are no prospective, randomized, interventional studies on the long-term cardiovascular effects of abuse of AAS. In this review we have studied the relevant literature regarding several risk factors for cardiovascular disease where the effects of AAS have been scrutinized: 1 Echocardiographic studies show that supraphysiologic doses of AAS lead to both morphologic and functional changes of the heart. These include a tendency to produce myocardial hypertrophy Fig. However, the clinical significance of this effect remains modest.

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Abuse of anabolic androgenic steroids AAS has been linked to a variety of different cardiovascular side effects. In case reports, acute myocardial infarction is the most common event presented, but other adverse cardiovascular effects such as left ventricular hypertrophy, reduced left ventricular function, arterial thrombosis, pulmonary embolism and several cases of sudden cardiac death have also been reported.

However, to date there are no prospective, randomized, interventional studies on the long-term cardiovascular effects of abuse of AAS. In this review we have studied the relevant literature regarding several risk factors for cardiovascular disease where the effects of AAS have been scrutinized: 1 Echocardiographic studies show that supraphysiologic doses of AAS lead to both morphologic and functional changes of the heart.

These include a tendency to produce myocardial hypertrophy Fig. However, the clinical significance of this effect remains modest. The concomitant effects on the humoral coagulation cascade are more complex and include activation of both pro-coagulatory and fibrinolytic pathways.

A degree of reversibility seems to be consistent, though. The most prominent changes are concomitant elevations of LDL and decreases of HDL, effects that increase the risk of coronary artery disease. And finally, 6 the use of AAS appears to confer an increased risk of life-threatening arrhythmia leading to sudden death, although the underlying mechanisms are still far from being elucidated.

Taken together, various lines of evidence involving a variety of pathophysiologic mechanisms suggest an increased risk for cardiovascular disease in users of anabolic androgenic steroids. This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable.

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Full-text links Cite Favorites. Abstract Abuse of anabolic androgenic steroids AAS has been linked to a variety of different cardiovascular side effects. Similar articles [Cardiovascular side effects of anabolic-androgenic steroids]. Kindermann W. PMID: German. Cardiac and metabolic effects of anabolic-androgenic steroid abuse on lipids, blood pressure, left ventricular dimensions, and rhythm.

Achar S, et al. Am J Cardiol. Adverse cardiovascular effects of anabolic steroids: pathophysiology imaging. Golestani R, et al. Eur J Clin Invest. Epub Feb 2. PMID: Review. Chang S, et al. Semin Thromb Hemost. Epub Sep Effects of androgenic-anabolic steroids in athletes.

Hartgens F, Kuipers H. Hartgens F, et al. Sports Med. Show more similar articles See all similar articles. Zhang B, et al. Front Endocrinol Lausanne. Rosca AE, et al. Medicina Kaunas. Long-term anabolic steroids in male bodybuilders induce cardiovascular structural and autonomic abnormalities. Barbosa Neto O, et al. Clin Auton Res. Epub Oct PMID: Androgenic-anabolic steroids inhibited post-exercise hypotension: a case control study.

Junior JFCR, et al. Braz J Phys Ther. Epub Jul Gentil P, et al. Eur J Transl Myol. Show more "Cited by" articles See all "Cited by" articles.

Publication types Review Actions. Echocardiography Actions. Humans Actions. Substances Anabolic Agents Actions. Lipids Actions. Steroids Actions. Full-text links [x] Springer. Copy Download.

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Androgenic Anabolic Steroid Abuse and the Cardiovascular System

Anabolic androgenic steroid AAS use increased dramatically among adolescent males. This review focuses on studies using animal models of AAS exposure during adolescence which is a hormonally sensitive developmental period. AAS exposure during this critical period has wide-ranging consequences, including increased dendritic spine density, altered brain serotonin levels and escalated aggression in response to physical provocation. Human data suggest that AAS induces indiscriminate and unprovoked aggression often described as "'roid rage". However, animal studies indicate that the behavioral impact of AAS is modulated by experiential and social contingencies, a perceived provocation, and the chemical composition of the AAS.

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Impact of Anabolic Androgenic Steroids on Adolescent Males

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[Recreational athletes and doping--a survey in 11 gyms in the area of Frankfurt/Main].

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