HIPERVITAMINOSIS B PDF

Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. Not surprisingly, a rise of the cobalamin concentration in serum is one of the diagnostic criteria for the latter two diseases. The increase in circulating cobalamin levels is predominantly caused by enhanced production of haptocorrin.

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Elevated levels of serum cobalamin may be a sign of a serious, even life-threatening, disease. Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera and also the hypereosinophilic syndrome can result in elevated levels of cobalamin. Not surprisingly, a rise of the cobalamin concentration in serum is one of the diagnostic criteria for the latter two diseases.

The increase in circulating cobalamin levels is predominantly caused by enhanced production of haptocorrin. Several liver diseases like acute hepatitis, cirrhosis, hepatocellular carcinoma and metastatic liver disease can also be accompanied by an increase in circulating cobalamin. Altogether it can be concluded that an observed elevation of cobalamin in blood merits the a full diagnostic work up to assess the presence of disease.

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Ermens AA, et al. Ned Tijdschr Geneeskd. PMID: Dutch. The pathophysiology of elevated vitamin B12 in clinical practice. Epub Feb PMID: Review. Chiche L, et al. Rev Med Interne. Epub Sep PMID: French. Vitamin B12 in health and disease: part I--inherited disorders of function, absorption, and transport. Kapadia CR. Our experience and a review]. Zulfiqar AA, et al. Medicina B Aires. Show more similar articles See all similar articles.

Urbanski G, et al. J Clin Med. Flores-Guerrero JL, et al. Micronutrient Deficiencies in Medical and Surgical Inpatients.

Berger MM, et al. Capelli I, et al. Higher maternal plasma folate, vitamin B 12 and homocysteine levels in women with preeclampsia. Pisal H, et al. J Hum Hypertens. Epub Jan PMID: Show more "Cited by" articles See all "Cited by" articles. Publication types Review Actions. MeSH terms Animals Actions. Humans Actions. Substances Vitamin B 12 Actions. Full-text links [x] Elsevier Science.

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DECRETO 4118 SALTA PDF

Hypervitaminosis

Hypervitaminosis is a condition of abnormally high storage levels of vitamins , which can lead to toxic symptoms. Specific medical names of the different conditions are derived from the vitamin involved: an excess of vitamin A , for example, is called hypervitaminosis A. Hypervitaminoses are primarily caused by fat-soluble vitamins D and A , as these are stored by the body for longer than the water-soluble vitamins. Generally, toxic levels of vitamins stem from high supplement intake and not from natural food.

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Significance of Elevated Cobalamin (Vitamin B12) Levels in Blood

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