Faut An additional 10 Guinea pigs were employed for blood transfusion. J Trauma Sonography for Trauma in Click here to sign up. References in classic literature? In the postoperative period, in kata patient intraabdominal abscess and in two patients wound infection occurred.
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Objective: Acute traumatic coagulopathy occurs after trauma with impairment of hemostasis and activation of fibrinolysis. Some endogenous substances may play roles in this failure of the coagulation system. Extracellular histone is one such molecule that has recently attracted attention. This study investigated the association between plasma histone-complexed DNA hcDNA fragments and coagulation abnormalities in pediatric trauma patients. Materials and methods: This prospective case-control study was conducted in pediatric patients with trauma.
Fifty trauma patients and 30 healthy controls were enrolled. Demographic data, anatomic injury characteristics, coagulation parameters, computerized tomography findings, trauma, and International Society on Thrombosis and Haemostasis disseminated intravascular coagulation ISTH DIC scores were recorded. Blood samples for hcDNA were collected and assessed by enzyme-linked immunosorbent assay. Results: Thirty-two patients had multiple trauma, while 18 patients had isolated brain injury.
There was an association between plasma hcDNA levels and trauma severity. Thirteen patients had acute coagulopathy of trauma shock ACoTS. Conclusion: This study indicated that hcDNA levels were increased in pediatric trauma patients and associated with the early phase of coagulopathy. Further studies are needed to clarify the role of hcDNA levels in mortality and disseminated intravascular coagulation.
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Figure 1. Receiver operating characteristic curve analyses of histone-complexed DNA. See this image and copyright information in PMC. Similar articles Disseminated intravascular coagulation or acute coagulopathy of trauma shock early after trauma? An observational study. Johansson PI, et al.
Crit Care. Epub Nov Russell RT, et al. PMID: Hemostasis during the early stages of trauma: comparison with disseminated intravascular coagulation. Oshiro A, et al. Clinical Trial. Gando S, et al. J Thromb Haemost. PMID: Review. Trauma, shock, and disseminated intravascular coagulation: lessons from the classical literature. Ann Surg. Show more similar articles See all similar articles. Overview of Children in the Emergency Department, CUP Statistical Brief Rockville, Agency for Healthcare Research and Quality.
Pediatric major trauma: an approach to evaluation and management. Emerg Med Clin North Am. Coagulopathy after severe pediatric trauma. Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes. Normalization of coagulopathy is associated with improved outcome after isolated traumatic brain injury.
J Clin Neurosci. MeSH terms Adolescent Actions. Blood Coagulation Tests Actions. Case-Control Studies Actions. Child Actions. Child, Preschool Actions. Female Actions. Fibrinolysis Actions. Hemostasis Actions. Humans Actions. Infant Actions. Male Actions. Prospective Studies Actions. Substances Histones Actions. DNA Actions. Copy Download.
Acute Traumatic Coagulopathy: The Value of Histone in Pediatric Trauma Patients
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